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Description
GLP 1 agonists are indicated for treating people who have diabetes, obesity or are at risk of cardiovascular disease related incidents. The drugs' off label use for cosmetic weight loss has sparked widespread interest. Synergistic associations of metformin and GLP1 receptor agonist use with adiposityrelated cancer incidence in people living with type 2 diabetes Henney 2026 Diabetes, Obesity and Metabolism Wiley Online Library PDF) Occupancy of Glucagon Like Peptide 1 receptor by Tirzepatide and SAR441255 measured with [68Ga]Ga DO3A exendin 4 PET in vivo. Common GLP 1 Weight loss Side Effects PillSorted Wegovy Pill: First Oral GLP 1 for Weight Loss (2025) GLP 1 is a Good Little Protein
![PDF) Occupancy of Glucagon Like Peptide-1 receptor by Tirzepatide and SAR441255 measured with [68Ga]Ga-DO3A-exendin-4/PET in vivo.](https://i1.rgstatic.net/publication/376277084_Occupancy_of_Glucagon_Like_Peptide-1_receptor_by_Tirzepatide_and_SAR441255_measured_with_68GaGa-DO3A-exendin-4PET_in_vivo/links/69217080abe27c41e51456a8/largepreview.png "PDF) Occupancy of Glucagon Like Peptide-1 receptor by Tirzepatide and SAR441255 measured with [68Ga]Ga-DO3A-exendin-4/PET in vivo.")
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Best in 7 days
Best in 7 days
Best in 7 days
Best in 7 days
4.8 ★★★★★
Based on 1522 reviews
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Product Reviews
★★★★★ 5
AMAZING!!
This stuff actually WORKS, Y'ALL! I was hopeful when I ordered but didn't totally know what to expect. But after using the entire tube I CAN SAY IT WORKS! I'll be 40 in a couple of weeks. A smoker for almost 25yrs and big time tanaholic and it shows on my face 😟, so I need help. The most noticeable difference is what it did to my crows feet. They're still there BUT NOT when I have just resting face. They show up when I laugh or smile, but if I just have a straight face I have ZERO crows feet now. I used it every night, a few times during the day (maybe like 5× max), but I kept it next to my bed and put it allover my face, with more attention to my eye area. I got it on 11-23 and started using that day. On 12-16 I thought I'd used it all up, so got mad and ordered a different product (same concept, just different brand). But realized I just needed to twist more and I had way more product left 😬. So like I said, I used this from 11-23 every night religiously until I ACTUALLY used it ALL on 1-4. I DO have a noticeable difference in skin texture, smoothness and definite hydration. The scent is barely there and the longevity is good, too. I mean I used this religiously and it lasted almost 6 weeks. The value for the money was great when I ordered it, it costs more now though. It IS a lil greasy, but I was using it at night so I didn't care and it didn't cause any breakouts 🙌🏼 I'm gonna try this new stuff I got since I already ordered it and see how I like it. If not then I'm buying this again for sure! I literally used every last drop 😂
**EDIT TO ADD**
I completely forgot to tell y'all what this did to my 11's!!! Idk the proper term, but the deep lines you get on the inside of your brows, especially noticeable when you frown or focus: VERY BIG CHANGE! I'm NOT claiming this will work on everyone but it's done wonders for me! My 11's are still here but they're nowhere as close to what they were! Not as deep or noticeable, soooo much smoother! I ordered a similar product, (different brand) and started using it on 1-5. Today is 1-30 and I'm already out of it so I came back to order THIS again, the Dr. Melaxin Balm stick. It lasts longer and works better than the high-end product that only lasted 25 days. THIS BALM STICK IS WHERE IT'S AT, Y'ALL!!
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Reviewed in the United States on January 6, 2026
★★★★★ 4
Great product for dry, sensitive under eyes, however does not really reduce wrinkles
Great moisturizer. While it’s marketed as reversing wrinkles that has not been my experience however I have very thin skin underneath my eyes that is often dry and very dark from allergies. I put this on every day and every night and I have noticed a huge difference in the way, my eyes look. I wouldn’t say it reduces wrinkles, but it definitely is really a great hydrator, especially if you have allergies. It’s very good for sensitive skin. I do use it all over my face, especially around my mouth area as well and again haven’t noticed that it really reduces my wrinkles, but it definitely helps. Hydrate all those sensitive problem areas. I liked it so much. I bought it twice.
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Reviewed in the United States on May 29, 2026
★★★★★ 3
Doesn't give instant results like those videos you see but still works good
Ive been seeing so many videos with different people saying how this stuff works instantly on their lines and bags under their eyes. I thought when I got it it was going to be oily because in those videos it literally looks like they have oil on their face. HOWEVER, this is more like a chapstick texture. I tried to use it on my eye bags as soon as I got it but I swear it almost made them look worse. Those videos showing them getting results instantly just aren't true. I've only been using it for a few days and I do see the lines on my forehead & between my eyes are definitely less noticeable so it is doing something so far! My bags however it's just done nothing noticeable for YET. That will probably take a couple weeks to show results. So long story short, if you're thinking about buying this thinking you're going to get the results from those videos going around you'll be disappointed but it does still give results. I will probably update after a couple weeks or however long it takes for my bags under my eyes to go away or to at least see results. My lines on my face aren't very prominent but my bags under my eyes are so we'll see.
Also this product isn't greasy I have an oily T zone and this doesn't make my face oily at all. If you don't like how it feels when you rub the stick on your face then use your hands and rub the product in to the skin and it will completely absorb the product.
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Reviewed in the United States on January 1, 2026
★★★★★ 5
One of the Most Useful Skincare Products I Own
Title: One of the Most Useful Products for Mature Skin — Smooths, Protects, and Works Beautifully Under Makeup
At 52 with post-menopausal dry, mature skin, I’m always looking for products that don’t just sit on the surface, but actually improve how my skin looks and behaves throughout the day. This surprised me in the best way.
This is not a treatment product, and it’s important to set that expectation upfront. This is a barrier-supporting, smoothing balm, and when you use it for what it is, it performs exceptionally well.
The texture is where it really wins. It’s a solid balm stick, but it glides effortlessly without dragging or pulling on the skin, which is critical for more delicate, mature areas. It melts just enough on contact and leaves behind a smooth, lightweight, conditioned finish that feels nourishing without being greasy or heavy.
From a formulation standpoint, this is built around silicones and emollients that give an immediate soft-focus effect, combined with oils and butters that help reinforce the moisture barrier. There’s also adenosine for long-term wrinkle support and collagen extract for conditioning, though this is not going to rebuild collagen or act like a corrective serum.
What it does do extremely well is improve the appearance of the skin instantly. It softens fine lines, reduces that dry, crepey look that can show up midday, and adds just enough slip and hydration to make the skin look healthier and more refined.
Where I really love this is under makeup.
It creates a smooth, hydrated base that helps foundation sit better and prevents it from catching on dry areas. It doesn’t pill, it doesn’t break anything down, and it adds that subtle cushion that mature skin really benefits from. I’ve also used it over makeup for touch-ups, and it works just as well without disturbing what’s underneath.
This has quickly become one of those products I keep within reach because it’s so practical. It’s not about transformation — it’s about maintenance, comfort, and immediate visual improvement, which, for mature skin, is often exactly what you need.
No irritation for me, and it layers seamlessly with the rest of my routine.
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Reviewed in the United States on May 5, 2026
★★★★★ 5
Consistency is the key
This product is amazing. You have to keep in mind that it doesn’t give instant results. However, consistent use will reveal wonders. I use my whole stick before I started to see results. When my stick was gone, is when I looked in the mirror and I was shocked. My forehead was tighter and lifted. My under eye bags had disappeared, and my eyes looked tighter. My skin was just so youthful looking. So I was like OK!! I need to order another one, I swear I didn’t think it was working at all until the sticker was gone. And I just woke up one morning and noticed a huge difference. I wonder if the changes will last?
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Reviewed in the United States on May 25, 2026
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